pS371-GPR88 (phospho-GPR88 Antibody)

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Agonist-induced Serine371 phosphorylation of GPR88-Receptor.

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Order number: 7TM0123C
Content: 100 µl
Host: Rabbit

Serine371 (S371) is a major phosphorylation site of the human GPR88 receptor.... more

Serine371 (S371) is a major phosphorylation site of the human GPR88 receptor. The pS371-GPR88 antibody detects phosphorylation in response to high-efficacy agonists. S371 phosphorylation is a key regulator of human GPR88 desensitization, β-arrestin recruitment and internalization.

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Alternative Names STRG, striatum-specific G-protein coupled receptor... more

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Alternative Names	STRG, striatum-specific G-protein coupled receptor
IUPHAR Target ID	123
UniProt ID	Q9GZN0
Western Blot (WB)	1:1000
Species Reactivity	Human
Host / Isotype	Rabbit / IgG
Class	Polyclonal
Immunogen	A synthetic phosphopeptide derived from human GPR88 around the phosphorylation site Ser371.
Form	Liquid
Purification	Antigen affinity chromatography
Storage buffer	Dulbecco's PBS, pH 7.4, with 150 mM NaCl, 0.02% sodium azide
Storage conditions	short-term 4°C, long-term -20°C

Figure 1. Agonist-induced Serine371 phosphorylation of GPR88-Receptor. Upper panel, HEK293... more

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Figure 1. Agonist-induced Serine371 phosphorylation of GPR88-Receptor. Upper panel, HEK293 cells stably expressing the GPR88 receptor (GPR88) and transiently GRK2 (Ratio GPR88 receptor:GRK2 = 10:1) were preincubated with serum-free media. After 2 hours cells were either not exposed or exposed to 100 nM of 2-PCCA for 30 minutes. Cells were lysed and immunoblotted with the anti-pS371-GPR88 antibody (7TM0123C) at a dilution of 1:1000. Lower panel, blot was stripped and reprobed with the phosphorylation-independent anti-GPR88 antibody (7TM0123N) to confirm equal loading of the gel.

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