Premium Immunohistochemistry-Grade 7TM Antibodies

G protein-coupled recptors (GPCRs) and heptahelical receptors (7TMR) are notoriously difficult to detect in fixed tissues using antibodies. For many of these receptors the cellular and subcellular localization remains a major challenge. 7TM Antibodies provides highly-characterized protein binding reagents for selected human and rodent GPCRs, which are well suited for efficient localization in formalin-fixed, paraffin-embedded tissues. Each of these antibodies has gone through advanced validation in transfected cells and native tissues using Western blot and immunohistochemistry. Where ever species cross-reactivity allowed, the verification process included validation using knockout mice (KO-Validated). We strictly adhere to the IUPHAR guidelines for receptor nomenclature.

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mGLUR5 (IHC-Grade), Metabotropic Glutamate...

The non-phospho-mGLUR5 receptor antibody is directed against the distal end of the carboxyl-terminal tail of human mGLUR5. It can be used to detect total mGLUR5 receptors in Western blots independent of phosphorylation. The mGLUR5...

£ 335.00 *

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NEW

LPA5 (IHC-Grade), Lysophosphatidic Acid...

The non-phospho-LPA5 receptor antibody is directed against the distal end of the carboxyl-terminal tail of human LPA5. It can be used to detect total LPA5 receptors in Western blots independent of phosphorylation. The LPA5 antibody can...

£ 335.00 *

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NEW

LPA3 (IHC-Grade), Lysophosphatidic Acid...

The non-phospho-LPA3 receptor antibody is directed against the distal end of the carboxyl-terminal tail of human LPA3. It can be used to detect total LPA3 receptors in Western blots independent of phosphorylation. The LPA3 antibody can...

£ 335.00 *

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NEW

GPR162 (IHC-Grade), G protein-coupled Receptor...

The non-phospho-GPR162 receptor antibody is directed against the distal end of the carboxyl-terminal tail of human GPR162. It can be used to detect total GPR162 receptors in Western blots independent of phosphorylation. The GPR162...

£ 335.00 *

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NEW

GPR150 (IHC-Grade), G protein-coupled Receptor...

The non-phospho-GPR150 receptor antibody is directed against the distal end of the carboxyl-terminal tail of human GPR150. It can be used to detect total GPR150 receptors in Western blots independent of phosphorylation. The GPR150...

£ 335.00 *

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NEW

GPR149 (IHC-Grade), G protein-coupled Receptor...

The non-phospho-GPR149 receptor antibody is directed against the distal end of the carboxyl-terminal tail of human GPR149. It can be used to detect total GPR149 receptors in Western blots independent of phosphorylation. The GPR149...

£ 335.00 *

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NEW

GPR148 (IHC-Grade), G protein-coupled Receptor...

The non-phospho-GPR148 receptor antibody is directed against the distal end of the carboxyl-terminal tail of human GPR148. It can be used to detect total GPR148 receptors in Western blots independent of phosphorylation. The GPR148...

£ 335.00 *

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NEW

GPR85 (IHC-Grade), G protein-coupled Receptor...

The non-phospho-GPR85 receptor antibody is directed against the distal end of the carboxyl-terminal tail of human GPR85. It can be used to detect total GPR85 receptors in Western blots independent of phosphorylation. The GPR85 antibody...

£ 335.00 *

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NEW

GPR75 (GP-IHC-Grade), G protein-coupled...

The non-phospho-GPR75 receptor antibody is directed against the distal end of the carboxyl-terminal tail of human GPR75. It can be used to detect total GPR75 receptors in Western blots independent of phosphorylation. The GPR75 antibody...

£ 335.00 *

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NEW

GPR37L1 (IHC-Grade), G protein-coupled Receptor...

The non-phospho-GPR37L1 receptor antibody is directed against the distal end of the carboxyl-terminal tail of human GPR37L1. It can be used to detect total GPR37L1 receptors in Western blots independent of phosphorylation. The GPR37L1...

£ 335.00 *

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NEW

GPR68 (IHC-Grade), G protein-coupled Receptor...

The non-phospho-GPR68 receptor antibody is directed against the distal end of the carboxyl-terminal tail of human GPR68. It can be used to detect total GPR68 receptors in Western blots independent of phosphorylation. The GPR68 antibody...

£ 335.00 *

Details

NEW

GPBA (IHC-Grade), Bile Acid Receptor Antibody

The non-phospho-GPBA receptor antibody is directed against the distal end of the carboxyl-terminal tail of human GPBA. It can be used to detect total GPBA receptors in Western blots independent of phosphorylation. The GPBA antibody can...

£ 335.00 *

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Rabbit Monoclonal

KD-Validated

NEW

SST3 [UMB5] (RM-IHC-grade), Somatostatin...

The SST3 receptor antibody is directed against the distal end of the carboxyl-terminal tail of human Somatostatin Receptor 3. In can be used to detect total SST3 receptors in Western blots independent of phosphorylation. The SST3...

£ 495.00 *

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Rabbit Monoclonal

NEW

V1A [UMB21] (RM-IHC-Grade-Vasopressin Receptor...

The non-phospho-V1A antibody is directed against the distal end of the carboxyl-terminal tail of human V1A. It can be used to detect total V1A receptors in Western blots independent of phosphorylation. The V1A antibody can also be used...

£ 495.00 *

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Rabbit Monoclonal

NEW

CT [UMB25] (RM-IHC-Grade-Calcitonin Receptor...

The non-phospho-CT antibody is directed against the distal end of the carboxyl-terminal tail of human CT. It can be used to detect total CT receptors in Western blots independent of phosphorylation. The CT antibody can also be used to...

£ 495.00 *

Details

Rabbit Monoclonal

NEW

BB2 [UMB17] (RM-IHC-Grade-Bombesin Receptor 2...

The non-phospho-BB2 antibody is directed against the distal end of the carboxyl-terminal tail of human BB2. It can be used to detect total BB2 receptors in Western blots independent of phosphorylation. The BB2 antibody can also be used...

£ 495.00 *

Details

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For further reading refer to:

Fischer T, Doll C, Jacobs S, Kolodziej A, Stumm R, Schulz S. Reassessment of sst2 somatostatin receptor expression in human normal and neoplastic tissues using the novel rabbit monoclonal antibody UMB-1. J Clin Endocrinol Metab. 2008 Nov;93(11):4519-2 4. doi: 10.1210/jc.2008-1063. Epub 2008 Aug 12. PubMed PMID: 18697876.

Fischer T, Nagel F, Jacobs S, Stumm R, Schulz S. Reassessment of CXCR4 chemokine receptor expression in human normal and neoplastic tissues using the novel rabbit monoclonal antibody UMB-2. PLoS One. 2008;3(12):e4069. doi: 10.1371/journal.pone.0004069. Epub 2008 Dec 31. PubMed PMID: 19116653; PubMed Central PMCID: PMC2605258.

Lupp A, Hunder A, Petrich A, Nagel F, Doll C, Schulz S. Reassessment of sst(5) somatostatin receptor expression in normal and neoplastic human tissues using the novel rabbit monoclonal antibody UMB-4. Neuroendocrinology. 2011;94(3):255-64. doi: 10.1159/000329876. Epub 2011 Sep 27. PubMed PMID: 21952553.

Lupp A, Richter N, Doll C, Nagel F, Schulz S. UMB-3, a novel rabbit monoclonal antibody, for assessing μ-opioid receptor expression in mouse, rat and human formalin-fixed and paraffin-embedded tissues. Regul Pept. 2011 Feb 25;167(1):9-13. doi: 10.1016/j.regpep.2010.09.004. Epub 2010 Sep 17. PubMed PMID: 20851148.

Saaber F, Schütz D, Miess E, Abe P, Desikan S, Ashok Kumar P, Balk S, Huang K, Beaulieu JM, Schulz S, Stumm R. ACKR3 Regulation of Neuronal Migration Requires ACKR3 Phosphorylation, but Not β-Arrestin. Cell Rep. 2019 Feb 5;26(6):1473-1488.e9. doi: 10.1016/j.celrep.2019.01.049. PubMed PMID: 30726732.

Sánchez-Alcañiz JA, Haege S, Mueller W, Pla R, Mackay F, Schulz S, López-Bendito G, Stumm R, Marín O. Cxcr7 controls neuronal migration by regulating chemokine responsiveness. Neuron. 2011 Jan 13;69(1):77-90. doi: 10.1016/j.neuron.2010.12.006. PubMed PMID: 21220100.

Casar-Borota O, Heck A, Schulz S, Nesland JM, Ramm-Pettersen J, Lekva T, Alafuzoff I, Bollerslev J. Expression of SSTR2a, but not of SSTRs 1, 3, or 5 in somatotroph adenomas assessed by monoclonal antibodies was reduced by octreotide and correlated with the acute and long-term effects of octreotide. J Clin Endocrinol Metab. 2013 Nov;98(11):E1730-9. doi: 10.1210/jc.2013-2145. Epub 2013 Oct 3. PubMed PMID: 24092823.

Lee M, Lupp A, Mendoza N, Martin N, Beschorner R, Honegger J, Schlegel J, Shively T, Pulz E, Schulz S, Roncaroli F, Pellegata NS. SSTR3 is a putative target for the medical treatment of gonadotroph adenomas of the pituitary. Endocr Relat Cancer. 2015 Feb;22(1):111-9. doi: 10.1530/ERC-14-0472. Epub 2014 Dec 16. PubMed PMID: 25515731.

For further reading refer to: Fischer T, Doll C, Jacobs S, Kolodziej A, Stumm R, Schulz S. Reassessment of sst2 somatostatin receptor expression in human normal and neoplastic tissues using the... read more »

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For further reading refer to: